Nootropic Benefits and How it Works

Acetyl-L-Carnitine (ALCAR), Acetyl-L-Tyrosine, Artichoke (Leaf), Bacopa Monniera, Caffeine, Forskolin, Ginkgo Biloba, Huperzine A, Lion’ s Mane Mushroom, and Vitamin B12 are all natural ingredients that can be stacked together to form a Nootropic. Although each natural Nootropic has their own unique benefits if taken separately, it can be taken together to form synergistic effects. The general benefits of Natural Nootropics include:

Cognitive Enhancer

According to Dr. Corneliu Giurgea, if the natural ingredient does not enhance the user’s ability to learn, it is not considered a “Nootropic”. One of the main reason people take Nootropics is to improve their mental action, the processing speed for acquiring knowledge, and understanding of a task. The natural ingredients found in Nootropics promote the production of acetylcholine which is the neurotransmitter linked with learning. High acetylcholine improves the magnitude of neurotransmissions to the cortex. Additionally, it restrains the amount of glutamate release, which suppresses feedback excitation of the cortex. The overall effect is to make the cortical circuits respond quickly to relevant sensory input while decreasing excitatory feedback that can hinder memory retrieval. To understand how it works, one must recognize that the brain is a network of billions of independent neurons connected to over thousands of others of neurons by synapses. These synapses communicate using acetylcholine to send signals. Some Nootropics form new synapses which open more bridges for communication, while others increase the levels of these neurotransmitters. With new neuron cells and the improved synaptic communication, it enhances the proliferation and growth of dendrites – the branched nerve cell extensions where neural impulses travel – boosting neural signaling. The brain activity increases which improves neural impulse transmission enhances memory and thinking abilities, thus increasing neuroplasticity. Additionally, by optimizing the brain’s connection this results in one’s thoughts processing faster, helping to store and recall more information through memory, and may even enhance the way the right and left brain work together. Some Natural Nootropics has monoamine oxidase inhibiting properties which keep the mood-related neurotransmitter (norepinephrine, serotonin, dopamine) in balance and gives the user a sensation of mental clarity and focus.

Vasodilator of the Brain

Another one of Nootropic benefits is that it acts as a vasodilator – initiates dilation of blood vessels, which decreases blood pressure – next to the small arteries and veins in the brain. This increases the blood flow throughout the body, which allows important nutrient and oxygen to flow to the brain. Therefore, the greater the supply of nutrient, oxygen, and glucose, the greater amount of energy will the brain generate. The brain will work more efficiently by absorbing the nutrients and oxygen thoroughly and faster, due to the improved cerebral circulation. How it works is that the Nootropic inhibits the platelet activating factor receptor, which enhances the circulation throughout the body and brain by widening the blood vessels and making the blood less sticky. Additionally, the Nootropic benefits are that it has the ability to cross the blood-brain barrier making it easier to reach the brain directly.


Nootropic benefits the brain by acting as an antioxidant to regulate or remove harmful substances from the brain. It reduces the inflammation occurrence in the brain during the neuron maintenance process. The neurons get damaged by beta-amyloids, glutamate, and peroxides, hence it is essential to repair the cell compartments due to neurotransmitter purposes. The maintenance process protects the brain from toxins, minimizes the effects of brain aging, and contributes to the stimulation of new neuron cells. How it works is that some Natural Nootropics increase the amount of Nerve Growth Factor in the brain. Nerve growth factor is a neurotrophin which is a small secreted protein that is crucial for the survival, maintenance, proliferation and growth of neurons. It is one of the essential building blocks of neuroplasticity and brain health. The nerve growth factor advocates the growth of axons, nerve cells extension where impulses are conducted. Therefore, the more axons that exist, the better the overall function of the brain. The increase of nerve growth factor enhances cognition by promoting myelination, the growth of the lipid and protein sheath that covers and protects the axons. The myelin increases the speed at which impulses travel along the axon by increasing the resistance of the neural cell walls and preventing the impulses from dispersing or leaving the axon. To repair and regrow the damaged axon, the myelination lays the foundation to aid the process. This is vital for protecting the brain from aging or diseases such as Alzheimer’s because it potentially slows or even prevents the cognitive diseases connected with advanced age.

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